 |
Indication & Dosage |
|
| |
|
| Precautions |
History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion; asthma or allergic disorders; dehydrated patients; uncontrolled hypertension; impaired renal or hepatic function; elderly; pregnancy. Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Aspirin: GI disturbances; prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus. Clopidogrel: Dyspepsia, abdominal pain, nausea, vomiting, flatulence, constipation, gastritis, gastric and duodenal ulcers. Serious events include bleeding and GI haemorrhage. GI upset, diarrhoea, paraesthesia, vertigo, headache, dizziness, leucopaenia, eosinophilia, rash; pruritus and rashes. |
| |
|
| Adverse Drug Reactions |
Aspirin: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (childn <12 yrs). Hepatotoxicity; CNS depression, which may lead to coma; CV collapse, resp failure; paroxysmal bronchospasm and dyspnoea. Clopidogrel: Bleeding disorders including GI intracranial haemorrhage. |
| |
|
| Interactions |
Aspirin: Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone.
Clopidogrel: Co-administration of clopidogrel with NSAIDs may increase the risk of stomach and intestinal bleeding. At high conc in the blood, clopidogrel inhibits the activity of enzyme metabolising warfarin leading to an increased warfarin levels thus increasing the risk of bleeding due to over-thinning of the blood. High doses of clopidogrel inhibit cytochrome P-450 (CYP2C9). Clopidogrel may interfere with the metabolism of phenytoin, tamoxifen, torasemide, fluvastatin and some NSAIDs. Caution should be taken in admin of clopidogrel with these agents. |
| |
|
|
|
